ABSTRACT
Objectives: Our aim was to evaluate the impact of neutrophil to lymphocyte ratio [NLR] in patients with metastatic testicular cancer [tCa]
Design: Retrospective view of prospective recorded data
Setting: Clinical study was conducted at multicentre between May 2010 and September 2016
Subjects: Patients with tCa who underwent radical orchiectomy were enrolled. Similar surgical methods, laboratory analyses, and radiologic examinations were performed and all patients were divided into 2 groups. Group 1 [n = 108] consisted of patients with non-metastatic testicular cancer; Group 2 [n = 38] consisted of patients with metastatic [solid organ-lymph node metastasis] tCa
Intervention: Radical orchiectomy, blood sample
Main outcome measures: Demographic, preoperative, and postoperative data were noted. Postoperative complications were interpreted according to modified Clavien classifications. Statistical significant p was p
Results: Mean follow-up was 36.4 [4 - 72] months. Mean age was 39 years [19 - 71 years]. There were significant differences between groups in preoperative NLR, tCa markers and diameter of tumour [p = 0.03, p <0.001, p = 0.01, respectively]. Besides, invasion to lymphovascular, rete testis, cord, epididymis, and surgical margin positivity, postoperative tCa markers were significantly higher in group 2 than group 1. Area under ROC curve was 0.69, [p <0.001] and cut-off value for NLR was 3.11 in terms of any metastasis. There was no serious complication after operation. Five patients experienced wound infections [Clavien 1]
Conclusions: Preoperative NLR could help us to predict lymph node and solid organ metastasis in patients with tCa. If the NLR is over 3.1, clinicians should be aware of metastasis
ABSTRACT
The purpose of this study is to investigate the association of glycemic control prior to TUR-P and postoperative urethral stricture development. Of the 168 patients with a diagnosis of urethral stricture, who underwent internal urethrotomy in our hospital were retrospectively analyzed for this study. 98 patients who underwent monopolar TUR-P in our hospital previously and were developed urethral stricture were divided into two groups as diabetic and nondiabetic. Based on their HbA1c concentrations, diabetics were allocated to two groups with good [HbA1c 6, 5%] glycemic control. Time to internal urethrotomy and the other operative parameters were compared among groups. Time to internal urethrotomy after TUR-P was significantly shorter in diabetic patients with poor glycemic control than Group 1 and Group 2 [P = 0, 02, P = 0,012] but no significant difference was found between Group 1 and Group 2 [P = 0,368]. There was no significant difference in the mean diagnosed and resected prostate wight among groups. There was no significant difference in the mean resection time and the mean time to urethral catheter removal among groups. Especially in poor glycemic control patients, urethral stricture development was seen in the early period after TUR-P. For this reason, in the elective TUR-P scheduled poor glycemic controlled patients the operation should be done after glycemic control
ABSTRACT
To investigate if free PSA [fPSA] and total PSA [tPSA] values obtained from simultaneously collected urine, fresh and dried on filter paper, reflect the serum free and total PSA. The sera and 20 cc first voided urine from 33 consecutive men aged between 40 and 84 [mean 61 +/- 12], were collected in the morning and delivered to the laboratory. Three different aliquots of 100 microgram urine were taken with automatic pipette and dropped on 3 certain areas of a filter paper and allowed to dry for each patient. On each paper, borders of dried urine were marked. PSA values were obtained from the sera and fresh urine samples and recorded. Later on particular days dried urine samples were dissolved and eventually PSA values were derived and recorded again. The results were compared to each other. Correlations were evaluated by using an SPSS statistics program. Serum PSA values correlated weakly [r <0.24] with fresh and dried urine PSA values. While PSA in fresh and dried urine samples showed strong correlation [0.5< r < 0.74], a very strong correlation [r >0.75] among PSA values of dried urine samples of 1-day, 7- and 28-days, were seen. We conclude that PSA values obtained from fresh and dried urine could not reflect serum PSA values. But, because dried urine on a filter paper can be stable for years, it could be used for forensic purposes
Subject(s)
Humans , Male , Urine , Prostate-Specific Antigen/blood , Prostatic NeoplasmsABSTRACT
Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents are most frequently antibacterial drugs. We present a patient with acute generalized exanthematous pustulosis caused by methylene blue and indigotin dyes.